Many of today’s challenges that confront society are complex and dynamic and require new perspectives, new ways of looking at problems and issues, in order to be able to come to solutions that could not be found before. This process is called reframing and we suggest that one of the key stages in this process is thematic research, the search for themes that underlie these complex challenges. These themes generally turn out to be human themes, related to socio-emotional aspects of life. In this paper we report our experiences and lessons learned from a series of cases in which we experimented with various approaches to do this thematic research.