The research explores what the SDG Framework, on the basis of the two major SDG challenges -the complexity challenge and the silo challenge-, are demanding of HEIs in terms of SDG Governance, the formulation of its Third Mission, its internal alignment to integrate the SDG and equip the Research and Educational departments with the right SDG competences. The research uses the conceptual approach of Intended SDG Policies, Actual SDG Practice and SDG Perceptions. Recent and relatively young SDG literature is explored and it draws conclusions that there are assumptions on the feasibility of achieving them. Are SDGs aspirational or inspirational? And should the Framework be considered a temporarily binding guidance rather than a global enforcement mechanism to prevent depletion of our social and natural capital? Much SDG research stops at providing analytical frameworks and tools to grapple with the complexity of SDG’s synergies, tradeoffs and spill-over effects. Some literature and tools are available on SDG pathways of urgency and priority ranking but this contradicts the Transformational claims of the SDGs of being Integrative, Indivisible and Universal. A theoretical and practical gap is observed how the SDGs must be viewed in the global community of national policies. But also as a derivative : How can organisations, private and public, view and address the challenges of the SDG Framework?