Worldwide entrepreneurship education (EE) is gaining popularity as an employability skill to prepare learners for a future of adaptability and lifelong learning. Its scholarship, however, is concerned that we have lost sight of what works, why, and how in EE. This is especially true for such novel learning objectives as preparation for lifelong learning. This quasi-experimental, mixed methods research sought answers to the question: of how EE pedagogy influences students’ self-directed learning readiness (SDLR). Statistically significant relations were found, especially between self-efficacy and SDLR. The impact of EE was found to be highly significant, which was explained by the effect of a stage-wise, mixed pedagogy approach to teaching/learning. Enhancement of self-efficacy and motivation for self-directed learning was found to benefit from a continuous cyclical teaching-learning process combining passive, participative and self-steered learning within and throughout each step of the learning process, in simulated and authentic learning contexts.